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The stem cell and tissue engineering research in Chinese ophthalmology
GE Jian, LIU Jingbo
《医学前沿(英文)》 2007年 第1卷 第1期 页码 6-10 doi: 10.1007/s11684-007-0002-x
关键词: available observable neuroregeneration protection function reconstruction
Progress and perspectives of neural tissue engineering
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 401-411 doi: 10.1007/s11684-015-0415-x
Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient’s quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author’s group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.
Microorganism-derived biological macromolecules for tissue engineering
《医学前沿(英文)》 2022年 第16卷 第3期 页码 358-377 doi: 10.1007/s11684-021-0903-0
关键词: biological macromolecules regenerative medicine tissue engineering exopolysaccharide carbohydrate
Tissue engineering of cartilage, tendon and bone
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 61-69 doi: 10.1007/s11684-011-0122-1
Tissue engineering aims to produce a functional tissue replacement to repair defects. Tissue reconstruction is an essential step toward the clinical application of engineered tissues. Significant progress has recently been achieved in this field. In our laboratory, we focus on construction of cartilage, tendon and bone. The purpose of this review was to summarize the advances in the engineering of these three tissues, particularly focusing on tissue regeneration and defect repair in our laboratory. In cartilage engineering, articular cartilage was reconstructed and defects were repaired in animal models. More sophisticated tissues, such as cartilage in the ear and trachea, were reconstructed both in vitro and in vivo with specific shapes and sizes. Engineered tendon was generated in vitro and in vivo in many animal models with tenocytes or dermal fibroblasts in combination with appropriate mechanical loading. Cranial and limb bone defects were also successfully regenerated and repaired in large animals. Based on sophisticated animal studies, several clinical trials of engineered bone have been launched with promising preliminary results, displaying the high potential for clinical application.
关键词: Tissue engineering cartilage bone tendon recent advances
Current advances for bone regeneration based on tissue engineering strategies
Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian
《医学前沿(英文)》 2019年 第13卷 第2期 页码 160-188 doi: 10.1007/s11684-018-0629-9
关键词: bone tissue engineering stem cell bone scaffold growth factor bone regeneration
Fabrication of scaffolds in tissue engineering: A review
Peng ZHAO, Haibing GU, Haoyang MI, Chengchen RAO, Jianzhong FU, Lih-sheng TURNG
《机械工程前沿(英文)》 2018年 第13卷 第1期 页码 107-119 doi: 10.1007/s11465-018-0496-8
Tissue engineering (TE) is an integrated discipline that involves engineering and natural science in the development of biological materials to replace, repair, and improve the function of diseased or missing tissues. Traditional medical and surgical treatments have been reported to have side effects on patients caused by organ necrosis and tissue loss. However, engineered tissues and organs provide a new way to cure specific diseases. Scaffold fabrication is an important step in the TE process. This paper summarizes and reviews the widely used scaffold fabrication methods, including conventional methods, electrospinning, three-dimensional printing, and a combination of molding techniques. Furthermore, the differences among the properties of tissues, such as pore size and distribution, porosity, structure, and mechanical properties, are elucidated and critically reviewed. Some studies that combine two or more methods are also reviewed. Finally, this paper provides some guidance and suggestions for the future of scaffold fabrication.
关键词: tissue engineering scaffolds electrospinning 3D printing molding techniques conventional methods
Visualization of vascular ultrastructure during osteogenesis by tissue engineering technique
ZHANG Kaigang, ZENG Bingfang, ZHANG Changqing
《医学前沿(英文)》 2007年 第1卷 第2期 页码 181-184 doi: 10.1007/s11684-007-0034-2
关键词: feasibility engineering osteogenesis vascularization microscopy
Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region
Zhiyuan Zhang
《医学前沿(英文)》 2011年 第5卷 第4期 页码 401-413 doi: 10.1007/s11684-011-0161-7
关键词: bone regeneration animal models translational strategies oral and maxillofacial region
Current progress on scaffolds of tissue engineering heart valves
DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping
《医学前沿(英文)》 2008年 第2卷 第3期 页码 229-234 doi: 10.1007/s11684-008-0043-9
Dongjiao ZHOU, Shaochuan SHEN, Junxian YUN, Kejian YAO, Dong-Qiang LIN
《化学科学与工程前沿(英文)》 2012年 第6卷 第3期 页码 339-347 doi: 10.1007/s11705-012-1209-1
关键词: cryogel scaffold tissue engineering dextran hyaluronate 3T3-L1 preadipocyte
张涤生
《中国工程科学》 2000年 第2卷 第10期 页码 21-25
组织工程是应用细胞生物学和工程学的原理研究和开发,以达到修复和重建损伤的组织或器官的外形和功能的生物替代物的一门新学科,是继细胞生物学和分子生物学后,人类生命科学发展史上又一新的里程碑,标志着医学将超越组织和器官移植的旧模式,进人制造组织和器官的新时代,将在21世纪中绽露头角。
文章简略介绍世界组织工程发展历史及各类组织和器官组织工程的研究现状,并介绍我国组织工程科研工作开展的最新情况。目前组织工程已有了迅猛发展,在不少方面已取得重大突破。由于其孕育的巨大科学价值_及广阔的研究和应用前景,因此加快我国组织工程的研究,尽早地投人临床应用,对我国医学科学事业和国民经济的发展具有重大意义。
李石营, 钱天梅, 王星辉, 刘杰, 顾晓松
《工程(英文)》 2017年 第3卷 第1期 页码 3-15 doi: 10.1016/J.ENG.2017.01.005
组织工程是医学科学中一个相对较新但发展迅速的领域。非编码RNA(ncRNA) 是不编码蛋白质的功能性RNA 分子,它们可以调节细胞的行为、改变组织的生物学环境。虽然以对ncRNA 作为治疗靶点尚未进入临床实践,但ncRNA 在组织工程中的应用已经吸引了越来越多的关注,而且对ncRNA 的调节作用和释放方法的深入探讨可以促进其在组织工程中的应用。本文简要介绍了ncRNA 在神经、皮肤、肝脏、血管和肌肉的调控作用和可能的释放方法及其潜在的治疗应用价值。
关键词: 组织工程 非编码RNA(ncRNA) microRNA(miRNA) 神经 皮肤 肝脏 血管系统 肌肉
Hybrid polymer biomaterials for bone tissue regeneration
Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma
《医学前沿(英文)》 2019年 第13卷 第2期 页码 189-201 doi: 10.1007/s11684-018-0664-6
关键词: hybrid polymer bone regeneration tissue engineering biomaterials
组织工程和给药技术中的三维光制造 Review
Rúben F. Pereira, Paulo J. Bártolo
《工程(英文)》 2015年 第1卷 第1期 页码 90-112 doi: 10.15302/J-ENG-2015015
组织工程中最有前景的方法就是将生物材料、细胞和生物活性分子结合加入人工的模拟环境,用以准确地模拟人体组织修复环境,并刺激组织修复和再生。这个环境必须在细胞或亚细胞尺度上模拟出尽可能接近原生细胞外基质的主要特性,只有这样此方法才会在临床应用上有效。光制造技术通过多层工艺,如对光敏预聚物的选区光交联反应,构建包含精确结构和多相材料组合的环境。细胞和治疗分子可以包含在初始水凝胶前体的溶液中,并加工成三维(3D)结构。近来,光制造也已被开发用来动态调节水凝胶的实时特性,加强控制细胞寿命和生物活性物质的传递。本文聚焦于利用3D光制造技术为组织再生和给药技术生产先进结构的相关研究,同时介绍了目前最先进的光制造技术,重点放在控制细胞生物活性因子分布形式的工作原理和生物制造方法上。因光制造技术具有工艺快速、时空控制、高分辨率和高精度等特性,故其在复杂的3D结构设计中扮演着重要角色。这种技术同样能够为组织再生构建适当的环境,并可调节治疗方法的实施状况。
标题 作者 时间 类型 操作
Current advances for bone regeneration based on tissue engineering strategies
Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian
期刊论文
Fabrication of scaffolds in tissue engineering: A review
Peng ZHAO, Haibing GU, Haoyang MI, Chengchen RAO, Jianzhong FU, Lih-sheng TURNG
期刊论文
Visualization of vascular ultrastructure during osteogenesis by tissue engineering technique
ZHANG Kaigang, ZENG Bingfang, ZHANG Changqing
期刊论文
Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region
Zhiyuan Zhang
期刊论文
Current progress on scaffolds of tissue engineering heart valves
DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping
期刊论文
Cryo-copolymerization preparation of dextran-hyaluronate based supermacroporous cryogel scaffolds for tissueengineering applications
Dongjiao ZHOU, Shaochuan SHEN, Junxian YUN, Kejian YAO, Dong-Qiang LIN
期刊论文
Hybrid polymer biomaterials for bone tissue regeneration
Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma
期刊论文